itraconazol

J - Antiinfectives For Systemic Use -> J02 - Antimycotics For Systemic Use -> J02A - Antimycotics For Systemic Use -> J02AC - Triazole Derivatives -> J02AC02 - Itraconazole
Administration category: Free Medicine group: antifungal Brand name: Trisporal

Safety margins

≥ 18 years
WeightROADosage
ROA:
po
Dosage:
min. 100mg 1 dd to max. 200mg 2 dd
ROA:
iv
Dosage:
min. 100mg 1 dd to max. 200mg 2 dd

Kidney function

≥ 18 years
ROAGFRDosageIntervalComments
ROA: iv
GFR:
<30
Dosage:
do not prescribe
Comments:
oraal mag wel
Renal elimination: 0%
Dosage: independent on kidney function

Renal function-replacement therapy

CAPD: Aanpassen van de dosis of het doseerinterval is niet nodig. Itraconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof hydroxypropylbetadex. Het is onbekend of hydroxypropylbetadex wordt verwijderd door peritoneaal dialyse

Hemo dialysis: Aanpassen van de dosis of het doseerinterval is niet nodig. Itraconazol is slecht oplosbaar en wordt intraveneus toegediend met de hulpstof hydroxypropylbetadex. Hydroxypropylbetadex wordt verwijderd door hemodialyse.

Interactions

Interaction with (ATC): Interaction with: Expected effect:
Interaction with (ATC):
A02BC - Proton Pump Inhibitors
Interaction with:
geldt niet voor drank
Expected effect:
verlaging absorptie itraconazol
Interaction with (ATC):
A02BA - H2-Receptor Antagonists
Interaction with:
geldt niet voor drank
Expected effect:
verlaging absorptie itraconazol
Interaction with (ATC):
A03FA02 - Cisapride
Interaction with:
Expected effect:
toename cardiotoxiciteit cisapride
Interaction with (ATC):
R06AX12 - Terfenadine
Interaction with:
Expected effect:
toename cardiotoxiciteit terfenadrine
Interaction with (ATC):
J01FA09 - Clarithromycin
Interaction with:
Expected effect:
verhoging plasmaconcentratie itraconazol
Interaction with (ATC):
C01AA05 - Digoxin
Interaction with:
Expected effect:
verhoging plasmaconcentratie digoxine
Interaction with (ATC):
N03AB02 - Phenytoin
Interaction with:
Expected effect:
sterke verlaging itraconazol plasmaconcentratie
Interaction with (ATC):
J05AG01 - Nevirapine
Interaction with:
Expected effect:
verhoging plasmaconcentratie nevirapine en itraconazol
Interaction with (ATC):
J05AE - Protease Inhibitors
Interaction with:
Expected effect:
verhoging plasmaconcentratie proteaseremmers
Interaction with (ATC):
J04AB02 - Rifampicin
Interaction with:
Expected effect:
verlaging plasmaconcentratie itraconazol
Interaction with (ATC):
J04AB04 - Rifabutin
Interaction with:
Expected effect:
verlaging plasmaconcentratie itraconazol
Interaction with (ATC):
L04AD01 - Ciclosporin
Interaction with:
Expected effect:
verhoging ciclosporineconcentratie in volbloed
Interaction with (ATC):
L04AD02 - Tacrolimus
Interaction with:
Expected effect:
verhoging plasmaconcentratie tacrolimus
Interaction with (ATC):
L04AA10 - Sirolimus
Interaction with:
Expected effect:
verhoging plasmaconcentratie sirolimus
Interaction with (ATC):
B01AA - Vitamin K Antagonists
Interaction with:
Expected effect:
toename werking orale anticoagulantia

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.
Metadata

Swab vid: M-2134.2
Updated: 06/16/2019 - 20:05
Status: Published

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